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January 13, 2012 Structure–activity relationship of pyrrole based S-nitrosoglutathione reductase inhibitors: Carboxamide modification
Xicheng Sun, Jian Qiu, Sarah A. Strong, Louis S. Green, Jan W.F. Wasley, Joan P. Blonder, Dorothy B. Colagiovannia, Adam M. Stout, Sarah C. Mutka, Jane P. Richards, Gary J. Rosenthal
The enzyme S-nitrosoglutathione reductase (GSNOR) is a member of the alcohol dehydrogenase family (ADH) that regulates the levels of S-nitrosothiols (SNOs) through catabolism of S-nitrosoglutathione (GSNO). GSNO and SNOs are implicated in the pathogenesis of many diseases including those in respiratory, gastrointestinal, and cardiovascular systems.
The pyrrole based N6022 was recently identified as a potent, selective, reversible, and efficacious GSNOR inhibitor which is currently in clinical development for acute asthma. We describe here the synthesis and structure–activity relationships (SAR) of novel pyrrole based analogs of N6022 focusing on carboxamide modifications on the pendant N-phenyl moiety.
Bioorganic & Medicinal Chemistry Letters, Volume 22, Issue 6, 15 March 2012, Pages 2338–2342 (More…Science Direct website) 
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