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- October 15, 2013 - N30 Announces Presentations at the 2013 North American Cystic Fibrosis Conference
- April 2, 2013 - N30 Announces Presentation of Preclinical Data at the Basic Science Meeting of the European Cystic Fibrosis Society
- March 13, 2013 - N30 Announces First Patient Treated in Clinical Trial of N6022 in Cystic Fibrosis
- October 8, 2012 - N30 Names Sherif Gabriel, Ph.D. as VP Research
- March 21, 2014 - Primary airway epithelial cells expanded with feeder cells and ROCK inhibitor for screening novel GSNOR inhibitors and CFTR correctorsPrimary airway epithelial cells expanded with feeder cells and ROCK inhibitor for screening novel GSNOR inhibitors and CFTR correctors
- March 21, 2014 - Identification of Novel, Efficacious F508del‐CFTR Correctors to Treat Cystic Fibrosis
- October 14, 2013 - Next generation F508del CFTR correctors using a YFP based high throughput screening assay
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- October 14, 2013 - A Novel GSNOR Inhibitor with Potent Bronchodilatory Effects and CFTR Potentiation Activity
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October 14, 2013 A Novel GSNOR Inhibitor with Potent Bronchodilatory Effects and CFTR Potentiation Activity
Joan Blonder, Kirsten Look, Xicheng Sun, Jinliang Sui, Jian Qiu, Charles Scoggin and Sherif Gabriel
Cystic fibrosis (CF) is a complex disease caused by a defect in the cystic fibrosis transmembrane conductance regulator (CFTR). Consequences of the CFTR defect include abnormal ion and fluid transport across epithelila tissues, leading to viscous mucus, infection, inflammation, and constriction which are most prevalent in the airways.
The most efficacious treatment for CF would therefore have the ability to attenuate multiple parameters associated with this disease. Previously, we have shown that pharmacological inhibition of S-nitrosoglutathione reductase (GSNOR) may mitigate some aspects of CF pathophysiology through the ability to preserve S-nitrosoglutathione (GSNO) levels and function, including the ability to modulate inflammation, airway constriction, and CFTR function.
In this study, we explore the bronchodilatory and CFTR potentiation activities of a novel GSNOR inhibitor. More…(1.8Mb)
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