Nitrosylated protein (SNOs) such as nitrosoglutathione (GSNO) have been shown to play important roles in governing nitric oxide (NO) signaling events such as nitrosation. The source of NO for S-nitrosation can be NO itself or other nitrosothiols such as GSNO.
While multiple nitric oxide synthases (NOS enzymes) govern NO synthesis, only s-nitrosoglutathione reductase (GSNOR) has been shown to be a selective GSNO reductase and can rapidly accelerate the metabolism of GSNO.
Given the dynamic equilibrium of the nitric oxide containing pool, GSNOR has a pivotal influence on the total SNO pool given its central role in SNO catabolism.